Connecting a Connectome to Behavior: An Ensemble of Neuroanatomical Models of C. elegans Klinotaxis

@article{Izquierdo2013ConnectingAC,
  title={Connecting a Connectome to Behavior: An Ensemble of Neuroanatomical Models of C. elegans Klinotaxis},
  author={Eduardo J. Izquierdo and Randall D. Beer},
  journal={PLoS Computational Biology},
  year={2013},
  volume={9}
}
  • E. Izquierdo, R. Beer
  • Published 1 February 2013
  • Biology, Computer Science, Medicine
  • PLoS Computational Biology
Increased efforts in the assembly and analysis of connectome data are providing new insights into the principles underlying the connectivity of neural circuits. However, despite these considerable advances in connectomics, neuroanatomical data must be integrated with neurophysiological and behavioral data in order to obtain a complete picture of neural function. Due to its nearly complete wiring diagram and large behavioral repertoire, the nematode worm Caenorhaditis elegans is an ideal… 
Optimal synaptic signaling connectome for locomotory behavior in Caenorhabditis elegans: Design minimizing energy cost
TLDR
The optimal connectivity pattern that matches the best locomotory data is the one in which all interneuron connections are inhibitory, even those terminating on motor neurons, and this finding is consistent with recent experimental data on cholinergic signaling in C. elegans.
Information Flow through a Model of the C. elegans Klinotaxis Circuit
TLDR
Despite large variations in the neural parameters of individual circuits, the overall information flow architecture circuit is remarkably consistent across the ensemble, suggesting structural connectivity is not necessarily predictive of effective connectivity and information flow analysis captures general principles of operation for the klinotaxis circuit.
The Si elegans project at the interface of experimental and computational Caenorhabditis elegans neurobiology and behavior.
OBJECTIVE In light of recent progress in mapping neural function to behavior, we briefly and selectively review past and present endeavors to reveal and reconstruct nervous system function in
Circuit and Behavioral Analysis of Klinotaxis in Caenorhabditis elegans
TLDR
This dissertation investigates the neural basis of the sensorimotor transformation underlying a spatial orientation strategy in the nematode Caenorhabditis elegans and finds a minimal neuronal network for klinotaxis to sodium chloride including the ASE, AIY, AIZ, and SMB neuron classes that displays left/right asymmetry across the sensory neuron, interneuron, and motor neuron levels.
From head to tail: a neuromechanical model of forward locomotion in Caenorhabditis elegans
  • E. Izquierdo, R. Beer
  • Medicine, Biology
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2018
TLDR
Analysis of the development and analysis of a model of forward locomotion that integrates the neuroanatomy, neurophysiology and body mechanics of the worm revealed that head motoneurons SMD and RMD are sufficient to drive dorsoventral undulations in the head and neck and that short-range posteriorly directed proprioceptive feedback is sufficient to propagate the wave along the rest of the body.
Generating an Executable Model of the Drosophila Central Complex
TLDR
This document demonstrates how NeuroArch and Neurokernel may be used to algorithmically construct and evaluate executable neural circuit models of the CX neuropils and their interconnects based upon currently available information regarding the geometry and polarity of the arborizations of identified local and projection neurons in the C X.
Past and Recent Endeavours to Simulate Caenorhabditis elegans
TLDR
This short paper reviews past and present endeavours to reveal and harvest the potential of nervous system function in C. elegans and suggests that both robotics and information and computation technology would strongly benefit if the working principles of nervous systems could be extracted and applied to the engineering of brain-mimetic computational architectures.
From head to tail: A neuromechanical model of forward locomotion in C. elegans
TLDR
Analysis of the development and analysis of a model of forward locomotion that integrates the neuroanatomy, neurophysiology and body mechanics of the worm revealed that head motoneurons SMD and RMD are sufficient to drive dorsoventral undulations in the head and neck and that short-range posteriorly-directed proprioceptive feedback is sufficient to propagate the wave along the rest of the body.
Potential role of a ventral nerve cord central pattern generator in forward and backward locomotion in Caenorhabditis elegans
TLDR
A computational model grounded in the available neuroanatomy and neurophysiology is developed and used to explore the space of possible configurations of the circuit that matched the neural traces observed during forward and backward locomotion in the worm, demonstrating that it is possible for the rhythmic contraction to be produced by a circuit present in the ventral nerve cord.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 112 REFERENCES
Evolution and Analysis of Minimal Neural Circuits for Klinotaxis in Caenorhabditis elegans
TLDR
A minimalistic neural network, comprised of an ON-OFF pair of chemosensory neurons and a pair of neck muscle motor neurons, is sufficient to generate realistic klinotaxis behavior, suggesting that the model may be operating according to principles similar to those of the biological network.
Structural Properties of the Caenorhabditis elegans Neuronal Network
TLDR
The wiring diagram reported here can help in understanding the mechanistic basis of behavior by generating predictions about future experiments involving genetic perturbations, laser ablations, or monitoring propagation of neuronal activity in response to stimulation.
Computational inference of the molecular logic for synaptic connectivity in C. elegans
TLDR
This work introduces an information theoretic measure of the multivariate synergy, a fundamental concept in systems biology, connecting the members of these gene sets, and demonstrates that their synergy is exceptionally high indicating joint involvement in pathways.
A Neural Network Model of Chemotaxis Predicts Functions of Synaptic Connections in the Nematode Caenorhabditis elegans
TLDR
Common patterns of connectivity between the model and biological networks suggest new functions for previously identified connections in the C. elegans nervous system, and it is shown that feedback regulates the latency between sensory input and behavior.
Neuronal substrates of complex behaviors in C. elegans.
TLDR
This work has identified gene products required for nervous system function and elucidated the molecular and neural bases of behaviors in the nematode Caenorhabditis elegans.
Optogenetic analysis of synaptic transmission in the central nervous system of the nematode Caenorhabditis elegans.
TLDR
A model in which the energetic cost of escape behaviours in C. elegans is tuned to the intensity of the threat is proposed, and it is found that escape probability mirrors the time course of synaptic current in the command neuron.
A Dynamic Network Simulation of the Nematode Tap Withdrawal Circuit: Predictions Concerning Synaptic Function Using Behavioral Criteria
TLDR
A novel strategy is used to predict the polarity configuration, i.e., the array of excitatory and inhibitory connections, of the nematode tap withdrawal circuit using an anatomically and physiologically justifiable dynamic network simulation of that circuit.
A Perimotor Framework Reveals Functional Segmentation in the Motoneuronal Network Controlling Locomotion in Caenorhabditis elegans
TLDR
The perimotor framework of observed connectivity and the segmented connectivity model give insights and advance the study of the neuronal infrastructure underlying locomotion in C. elegans and suggest that the tools used may be useful to interpret, simplify, and represent connectivity data of other motor systems.
The Neural Network for Chemotaxis to Tastants in Caenorhabditis elegans Is Specialized for Temporal Differentiation
TLDR
The results suggest that the C. elegans chemotaxis network is specialized for the temporal differentiation of chemosensory inputs, as required for chemosensation, and that the ASE class is unique in having both an on-cell and an off-cell.
Controlling interneuron activity in Caenorhabditis elegans to evoke chemotactic behavior
TLDR
Optogenetics and new optical tools are used to manipulate neural activity directly in freely moving animals to evoke chemotactic behaviour and it is discovered that controlling the dynamics of activity in just one interneuron pair (AIY) was sufficient to force the animal to locate, turn towards and track virtual light gradients.
...
1
2
3
4
5
...