Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton

  title={Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton},
  author={Andrea L Marat and Maria S Ioannou and Peter S McPherson},
  booktitle={Molecular biology of the cell},
The small GTPase Rab35 regulates endosomal membrane trafficking but also recruits effectors that modulate actin assembly and organization. Differentially expressed in normal and neoplastic cells (DENN)-domain proteins are a newly identified class of Rab guanine-nucleotide exchange factors (GEFs) that are grouped into eight families, each activating a common Rab. The members of one family, connecdenn 1-3/DENND1A-C, are all GEFs for Rab35. Why Rab35 requires multiple GEFs is unknown. We… CONTINUE READING


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