Conn: A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks
@article{WhitfieldGabrieli2012ConnAF,
title={Conn: A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks},
author={Susan L. Whitfield-Gabrieli and Alfonso Nieto-Casta{\~n}{\'o}n},
journal={Brain connectivity},
year={2012},
volume={2 3},
pages={
125-41
}
}Resting state functional connectivity reveals intrinsic, spontaneous networks that elucidate the functional architecture of the human brain. [] Key Method We have developed a functional connectivity toolbox Conn ( www.nitrc.org/projects/conn ) that implements the component-based noise correction method (CompCor) strategy for physiological and other noise source reduction, additional removal of movement, and temporal covariates, temporal filtering and windowing of the residual blood oxygen level-dependent…
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References
SHOWING 1-10 OF 82 REFERENCES
Correlations and anticorrelations in resting-state functional connectivity MRI: A quantitative comparison of preprocessing strategies
- BiologyNeuroImage
- 2009
The impact of global signal regression on resting state correlations: Are anti-correlated networks introduced?
- BiologyNeuroImage
- 2009
Anticorrelations in resting state networks without global signal regression
- Biology, PsychologyNeuroImage
- 2012
Reliable intrinsic connectivity networks: Test–retest evaluation using ICA and dual regression approach
- BiologyNeuroImage
- 2010
Consistent resting-state networks across healthy subjects
- Psychology, BiologyProceedings of the National Academy of Sciences
- 2006
Findings show that the baseline activity of the brain is consistent across subjects exhibiting significant temporal dynamics, with percentage BOLD signal change comparable with the signal changes found in task-related experiments.
Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization.
- PsychologyJournal of neurophysiology
- 2010
The brevity and robustness of fcMRI positions it as a powerful tool for large-scale explorations of genetic influences on brain architecture and how it can be combined with HARDI techniques to support the emerging field of human connectomics.
The global signal and observed anticorrelated resting state brain networks.
- BiologyJournal of neurophysiology
- 2009
Several characteristics of anticorrelated networks including their spatial distribution, cross-subject consistency, presence with modified whole brain masks, and existence before global regression are not attributable to global signal removal and therefore suggest a biological basis.
Investigations into resting-state connectivity using independent component analysis
- Computer Science, BiologyPhilosophical Transactions of the Royal Society B: Biological Sciences
- 2005
A probabilistic independent component analysis approach, optimized for the analysis of fMRI data, is reviewed and it is demonstrated that this is an effective and robust tool for the identification of low-frequency resting-state patterns from data acquired at various different spatial and temporal resolutions.
Detection of functional connectivity using temporal correlations in MR images
- BiologyHuman brain mapping
- 2002
The proposed methodology can reveal the presence and strength of functional connections in high‐level cognitive systems, as illustrated by application to the language system.










