Conjuring SNPs to detect associations

@article{Clark2007ConjuringST,
  title={Conjuring SNPs to detect associations},
  author={Andrew G. Clark and Jian Li},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={815-816}
}
Human genome-wide association studies pose a challenge in identifying significant disease associations from nearly half a million statistical tests. A new report describes an especially promising approach, recently applied to the Wellcome Trust Case Control Consortium data sets, that uses the correlated structure of genomic variation to impute genotypes at missing sites and to test association with both observed and imputed SNPs. 

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NATURE GENETICS © 20 07 N at ur e P ub lis hi ng G ro up ht tp :// w w w .n at ur e

S Romeo
Nat. Genet • 2007

The Wellcome Trust Case Control Consortium

J. Marchini, B. Howie, S. Myers, G. McVean, P. Donnelly
Nat . Genet . • 2007

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