Conjugative plasmids in bacteria of the ‘pre-antibiotic’ era

@article{Hughes1983ConjugativePI,
  title={Conjugative plasmids in bacteria of the ‘pre-antibiotic’ era},
  author={Victoria M. Hughes and Naomi Datta},
  journal={Nature},
  year={1983},
  volume={302},
  pages={725-726}
}
Antibiotic resistance is common in bacteria that cause disease in man and animals and is usually determined by plasmids. The prevalence of such plasmids, and the range of drugs to which they confer resistance, have increased greatly in the past 25 yr. It has become clear from work in many laboratories that plasmids have acquired resistance genes, of ultimately unknown origin, as insertions into their circular DNA. The intensive use of antibiotics since their introduction in the 1940s can… CONTINUE READING

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