Conjugation to polyethylene glycol polymer promotes aptamer biodistribution to healthy and inflamed tissues.

@article{Boomer2005ConjugationTP,
  title={Conjugation to polyethylene glycol polymer promotes aptamer biodistribution to healthy and inflamed tissues.},
  author={Ryan M. Boomer and Scott D. Lewis and Judith M. Healy and Markus Kurz and Charles C. Wilson and Thomas G. McCauley},
  journal={Oligonucleotides},
  year={2005},
  volume={15 3},
  pages={183-95}
}
Here, we examine biodistribution of radiolabeled aptamers and assess the relative ability of different stabilized aptamer compositions (mixed 2'-F/2'-O-Me; fully 2'-O-Me modified) to access inflamed tissues in a murine inflammation model. Biodistribution of 3H-labeled aptamers, including pegylated and unpegylated compositions, was assessed 3 hours… CONTINUE READING