Conjugation of monoclonal antibodies to a synthetic peptide substrate for protein kinase: a method for labelling antibodies with 32P.

@article{Foxwell1988ConjugationOM,
  title={Conjugation of monoclonal antibodies to a synthetic peptide substrate for protein kinase: a method for labelling antibodies with 32P.},
  author={Brian Michael J Foxwell and Heather A. Band and Jianyin Long and W. A. Jeffery and David Snook and Philip E. Thorpe and Graham Watson and Peter J Parker and Agamemnon A. Epenetos and Andrew M. Creighton},
  journal={British Journal of Cancer},
  year={1988},
  volume={57},
  pages={489 - 493}
}
In recent years, radiolabelled monoclonal antibodies have been evaluated for their use in the diagnosis and treatment of neoplastic disease. One isotope which has not been assessed for antibody targeting is 32P, even though it has many favourable radiobiological characteristics and has been used clinically for the treatment of certain neoplastic disorders such as polycythaemia rubra vera. The main drawback so far in using 32P has been the absence of a general method for phosphorylating… CONTINUE READING