Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity.

@article{Tighe2000ConjugationOI,
  title={Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity.},
  author={Helen Tighe and Kenji Takabayashi and Daniel Schwartz and Gary Van Nest and Stephen Tuck and Joseph J Eiden and Anne Kagey-Sobotka and Peter Socrates Creticos and Lawrence M. Lichtenstein and Hans L. Spiegelberg and Eyal Raz},
  journal={The Journal of allergy and clinical immunology},
  year={2000},
  volume={106 1 Pt 1},
  pages={124-34}
}
BACKGROUND Allergen immunotherapy is inconvenient and associated with the risk of anaphylaxis. Efforts to improve the safety of immunotherapy by means of chemical modification of allergens have not been successful because it greatly reduced their antigenicity. Recently, immunostimulatory DNA sequences (ISS or CpG motifs) have been shown to act as strong T(H)1 response-inducing adjuvants. OBJECTIVE We sought to determine whether conjugation of ISS to the major short ragweed allergen Amb a 1… CONTINUE READING

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