Conjugation of gold nanoparticles to polypropylene mesh for enhanced biocompatibility

@article{Grant2011ConjugationOG,
  title={Conjugation of gold nanoparticles to polypropylene mesh for enhanced biocompatibility},
  author={Daniel N. Grant and Jamie Benson and Matthew J Cozad and Ona E. Whelove and Sharon L. Bachman and Bruce Ramshaw and David A. Grant and Sheila A. Grant},
  journal={Journal of Materials Science: Materials in Medicine},
  year={2011},
  volume={22},
  pages={2803-2812}
}
Polypropylene mesh materials have been utilized in hernia surgery for over 40 years. However, they are prone to degradation due to the body’s aggressive foreign body reaction, which may cause pain or complications, forcing mesh removal from the patient. To mitigate these complications, gold nanomaterials were attached to polypropylene mesh in order to improve cellular response. Pristine samples of polypropylene mesh were exposed to hydrogen peroxide/cobalt chloride solutions to induce formation… 
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References

SHOWING 1-10 OF 38 REFERENCES
Biocompatibility of poly(ether)urethane-gold nanocomposites.
  • S. HsuC. TangH. Tseng
  • Materials Science, Engineering
    Journal of biomedical materials research. Part A
  • 2006
TLDR
The increased oxidative stability corresponded to the greater free radical scavenging ability of the nanocomposites, and better biocompatibility was associated with the surface morphological change in the presence of Au.
Characterization of bionanocomposite scaffolds comprised of amine-functionalized gold nanoparticles and silicon carbide nanowires crosslinked to an acellular porcine tendon.
TLDR
Investigation of two novel "bionanocomposite" materials in which either gold nanoparticles or silicon carbide nanowires were crosslinked to a porcine tendon resulted in scaffolds with improved resistance to enzymatic degradation and appropriate biocompatibility characteristics, thus warranting further study of these materials for soft tissue repair and tissue engineering applications.
Biostability and biocompatibility of poly(ether)urethane containing gold or silver nanoparticles in a porcine model.
TLDR
The interdependency among antioxidation/biostability/biocompatibility of PU was demonstrated in this porcine model and the extent of biodegradation and that of foreign body reactions were highly associated in these nanocomposites.
Assessment of the biocompatibility of two novel, bionanocomposite scaffolds in a rodent model.
Two novel, bionanocomposite scaffolds were evaluated in a rodent model over the course of three months to determine whether these scaffolds possessed adequate biocompatibility characteristics to
Biocompatibility of PLGA/sP(EO-stat-PO)-Coated Mesh Surfaces under Constant Shearing Stress
TLDR
Good biocompatibility for this surface-modified mesh compared to a standard polypropylene-based mesh is demonstrated and represents a promising tool as a carrier for bioactive substances in the near future.
Characterization of Heavyweight and Lightweight Polypropylene Prosthetic Mesh Explants From a Single Patient
TLDR
The hypothesis was that heavyweight polypropylene would incite a more intense inflammatory response than lightweightpolypropylene and thus undergo greater oxidative degradation, and the results support this theory.
Materials characterization of explanted polypropylene hernia meshes.
TLDR
The results supported the hypothesis that oxidation is involved with the degradation of polypropylene hernia mesh materials, and identified physiochemical changes in the surface and bulk properties of explanted polypropene hernia meshes compared to pristinepolypropylene mesh materials.
Synthesis, characterization, and antibacterial activity of metal nanoparticles embedded into amphiphilic comb-type graft copolymers
The synthesis, spectroscopic characterization, and antimicrobial efficiency of gold and silver nanoparticles embedded in novel amphiphilic comb-type graft copolymers having good film-forming
Materials characterization of explanted polypropylene, polyethylene terephthalate, and expanded polytetrafluoroethylene composites: spectral and thermal analysis.
This study utilized spectral and thermal analysis of explanted hernia mesh materials to determine material inertness and elucidate reasons for hernia mesh explantation. Composite mesh materials,
A perspective on nanophase materials for orthopedic implant applications
In the past, synthetic conventional materials have not served as satisfactory implants. As an example, the current average lifetime of an orthopedic implant (such as hip, knee, ankle, etc.) is only
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