Conjugation of cell-penetrating peptides to parathyroid hormone affects its structure, potency, and transepithelial permeation.

@article{Kristensen2015ConjugationOC,
  title={Conjugation of cell-penetrating peptides to parathyroid hormone affects its structure, potency, and transepithelial permeation.},
  author={Mie Kristensen and A Marit de Groot and J. E. Berthelsen and Henrik Franzyk and Alice J. A. M. Sijts and Hanne M\orck Nielsen},
  journal={Bioconjugate chemistry},
  year={2015},
  volume={26 3},
  pages={477-88}
}
Delivery of therapeutic peptides and proteins by the use of cell-penetrating peptides (CPPs) as carriers has been suggested as a feasible strategy. The aim of the present study was to investigate the effect of conjugating a series of well-known CPPs to the biologically active part of parathyroid hormone, i.e., PTH(1-34), and to evaluate the effect with regard to secondary structure, potency in Saos-2 cells, immunogenicity, safety, as well as the transepithelial permeation across monolayers by… CONTINUE READING

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