Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers.

@article{Santra2001ConjugationOB,
  title={Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers.},
  author={Swadeshmukul Santra and Pengfei Zhang and Kemin Wang and Rovelyn Tapec and Weihong Tan},
  journal={Analytical chemistry},
  year={2001},
  volume={73 20},
  pages={4988-93}
}
A new molecular conjugation method has been developed to label biomolecules with optically stable metalorganic luminophores, such as tris(2,2'-bipyridyl)dichlororuthenium(II) hexahydrate (Rubpy), which are otherwise not possible for direct linking with the biomolecules. Unique biochemical properties of the biomolecule can, thus, be associated with photostable luminophores. This opens a general way to conjugate desired biomolecules using a sensitive signal transduction method. It also promotes… CONTINUE READING