Conjugation of androgens and estrogens by human breast tumors in vitro

@article{Raju1980ConjugationOA,
  title={Conjugation of androgens and estrogens by human breast tumors 
 
 in vitro
 
 
},
  author={U. Raju and A. Blaustein and M. Levitz},
  journal={Steroids},
  year={1980},
  volume={35},
  pages={685-695}
}
The metabolism of 3H-androstenedione (delta 4-A) and 3H-estriol (E3) was studied in 12 human breast tumors. Part of each tumor was analyzed for estrogen receptor content. Aliquots of tumor homogenates were incubated for 2 hr separately with 3H-delta 4-A and 3H-E3 in the presence of appropriate cofactors. No distinct differences emerged in the profiles of the unconjugated metabolites of 3H-delta 4-A, the major compounds in the approximate order of descendence being androsterone, androstanedione… Expand
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