Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies.

@article{Chackerian2001ConjugationOA,
  title={Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies.},
  author={Bryce Chackerian and Douglas R Lowy and John T. Schiller},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={108 3},
  pages={415-23}
}
High avidity and long-lasting autoantibodies to a self-polypeptide (TNF-alpha) were generated after parenteral vaccination of mice with low doses of virus-like particle-based (VLP-based) vaccines that were constructed by linking mouse TNF-alpha peptides to the surface of papillomavirus VLPs. High-titer autoantibodies were induced with or without coadministration of potent conventional adjuvants, but were enhanced by coadministration of CFA. Compared with immunization with the fusion protein… CONTINUE READING

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