Conjugation of LPS-derived oligosaccharides to proteins using oxime chemistry.

@article{KublerKielb2011ConjugationOL,
  title={Conjugation of LPS-derived oligosaccharides to proteins using oxime chemistry.},
  author={Joanna Kubler-Kielb},
  journal={Methods in molecular biology},
  year={2011},
  volume={751},
  pages={317-27}
}
Conjugates of bacterial polysaccharides covalently bound to a carrier protein are among licensed human vaccines. Immunization of adults and children with these vaccines results in induction of saccharide-specific antibodies composed mainly of the IgG class. Depending on the choice of coupling technique, saccharides can be attached to a protein by either… CONTINUE READING