Conjugation of A and B Blood Group Structures to Silica Microparticles for the Detection of Antigen-Specific B Cells.

@article{Slaney2016ConjugationOA,
  title={Conjugation of A and B Blood Group Structures to Silica Microparticles for the Detection of Antigen-Specific B Cells.},
  author={Anne Margaret Slaney and I Esm{\'e} Dijke and Mylvaganam Jeyakanthan and Caishun Li and Lu Zou and Patrice G.J. Plaza-Alexander and Peter J. Meloncelli and Jeremy A. Bau and Lenka L Allan and Todd L Lowary and L. Jared West and Christopher W. Cairo and Jillian M Buriak},
  journal={Bioconjugate chemistry},
  year={2016},
  volume={27 3},
  pages={
          705-15
        }
}
Silica microparticles were functionalized with A and B blood group carbohydrate antigens (A type I, A type II, B type I, and B type II) to enable the detection and monitoring of ABO antigen-specific B cells. Microparticles were prepared via the Stöber synthesis, labeled with an Alexafluor fluorescent dye, and characterized via TEM and fluorescence microscopy. The silica microparticles were functionalized with (3-aminopropyl)trimethoxysilane (APTMS), followed by the use of an established… CONTINUE READING
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