Conjugation of 5-azido-3-oxapentyl glycosides with thiolated proteins through the use of thiophilic derivatives

@article{FernndezSantana2004ConjugationO5,
  title={Conjugation of 5-azido-3-oxapentyl glycosides with thiolated proteins through the use of thiophilic derivatives},
  author={Violeta Fern{\'a}ndez-Santana and Raul Gonzalez-Lio and Jorge Sarracent-P{\'e}rez and vicente Verez-Bencomo},
  journal={Glycoconjugate Journal},
  year={2004},
  volume={15},
  pages={549-553}
}
5-Azido-3-oxa-pentyl beta-D-galactopyranoside was prepared from diethylene glycol monochlorohydrin and used as a model of oligosaccharide hapten. After deprotection, a series of amides bearing thiophilic groups had been obtained through the terminal amino function and essayed in coupling reactions with thiolated BSA. Also several Lewis human blood group oligosaccharides had been conjugated with thiolated BSA demonstrating the usefulness of the methodology. 
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