Conjugation and deamination of circulating dopamine: relationship between sulfated and free dopamine in man.

@article{Claustre1990ConjugationAD,
  title={Conjugation and deamination of circulating dopamine: relationship between sulfated and free dopamine in man.},
  author={J. Claustre and J. M. P{\'e}quignot and B Bui-xuan and Raoul Muchada and R M Cottet-Emard and Liliane Peyrin},
  journal={Journal of the autonomic nervous system},
  year={1990},
  volume={29 2},
  pages={175-81}
}
In order to assess the importance of conjugation in dopamine metabolism, we infused dopamine (20 nmol/kg/min, 1 h) to seven male subjects, then measured the kinetics of free and conjugated dopamine and DOPAC (deaminated dopamine) in plasma both during and after the infusion. Dopamine increased as early as 2 min after the start of the infusion, then reached a plateau and remained elevated on a level of 25 times the basal value. Dopamine sulfate and DOPAC followed very similar patterns and… CONTINUE READING

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