Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial.

@article{Ball2006ConjugatingBT,
  title={Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial.},
  author={Anthony R. Ball and Gabriele Casadei and Siritron Samosorn and John B. Bremner and Frederick M. Ausubel and Terence I. Moy and Kim Lewis},
  journal={ACS chemical biology},
  year={2006},
  volume={1 9},
  pages={594-600}
}
In bacteria, multidrug-resistance pumps (MDRs) confer resistance to chemically unrelated amphipathic toxins. A major challenge in developing efficacious antibiotics is identifying antimicrobial compounds that are not rapidly pumped out of bacterial cells. The plant antimicrobial berberine, the active component of the medicinal plants echinacea and golden seal, is a cation that is readily extruded by bacterial MDRs, thereby rendering it relatively ineffective as a therapeutic agent. However… CONTINUE READING

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