Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. In vivo studies in the rat.

@article{Heuman1991ConjugatesOU,
  title={Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. In vivo studies in the rat.},
  author={Douglas M. Heuman and Alan Scott Mills and John E McCall and Phillip B. Hylemon and William M. Pandak and Z Rano Vlahcevic},
  journal={Gastroenterology},
  year={1991},
  volume={100 1},
  pages={
          203-11
        }
}
The protective effect of ursodeoxycholate conjugates against bile salt hepatotoxicity was studied in chronic bile fistula rats. Taurochenodeoxycholate or taurodeoxycholate, infused intraduodenally at 24 or 16 mumols/100 g rat per hour, respectively, caused cholestasis and severe hepatocellular necrosis within 8 hours. In contrast, tauroursodeoxycholate or taurocholate at 48 mumols/100 g rat per hour were choleretic. Tauroursodeoxycholate was not hepatotoxic, whereas taurocholate produced… CONTINUE READING
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