Conjugates of Small Molecule Drugs with Antibodies and Other Proteins

  title={Conjugates of Small Molecule Drugs with Antibodies and Other Proteins},
  author={Yang Feng and Zhongyu Zhu and Weizao Chen and Ponraj Prabakaran and Kedan Lin and D. S. Dimitrov},
Conjugates of small molecule drugs with antibodies (ADCs) and with other proteins (protein-drug conjugates, PDC) are used as a new class of targeted therapeutics combining the specificity of monoclonal antibodies (mAbs) and other proteins with potent cytotoxic activity of small molecule drugs for the treatment of cancer and other diseases. A(P)DCs have three major components, antibody (targeting protein), linker and payload, the cytotoxic drug. Recently, advances in identifying targets… CONTINUE READING


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