Corpus ID: 34326099

Conjugated system of homo-aza-steroidal esters in cancer chemotherapy.

  title={Conjugated system of homo-aza-steroidal esters in cancer chemotherapy.},
  author={P. Catsoulacos and D. Catsoulacos},
  journal={Anticancer research},
  volume={14 6B},
  • P. Catsoulacos, D. Catsoulacos
  • Published 1994
  • Chemistry, Medicine
  • Anticancer research
  • The homo-aza-steroidal esters of conjugated carboxylic derivatives of nitrogen mustards are reviewed. Particularly we discuss the antitumor activity of cinnamic acid and benzoic acid mustard isomers, esters of homo-aza-steroids in which the mustard acid is linked to the C-3 or C17 position, while the lactam nucleus is in the D or A ring of the steroid respectively. The current literature indicates that the potential is due to the synergistic activity of both the steroidal lactam and the mustard… CONTINUE READING
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