Conjugated platinum(IV)-peptide complexes for targeting angiogenic tumor vasculature.

  title={Conjugated platinum(IV)-peptide complexes for targeting angiogenic tumor vasculature.},
  author={Sumitra Mukhopadhyay and Carmen M. Barn{\'e}s and Ariel Haskel and Sarah M. Short and Katie R Barnes and Stephen J Lippard},
  journal={Bioconjugate chemistry},
  volume={19 1},
The integrins alpha vbeta3 and alpha vbeta5 and the membrane-spanning surface protein aminopeptidase N (APN) are highly expressed in tumor-induced angiogenesis, making them attractive targets for therapeutic intervention. Both integrins and APN recognize a broad range of peptides containing RGD (Arg-Gly-Asp) and NGR (Asn-Gly-Arg) motifs, respectively. Here, we describe the design, synthesis, and characterization of a series of mono- and difunctionalized platinum(IV) complexes in which a… CONTINUE READING


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