Conjugated methyl sulfide and phenyl sulfide derivatives of oxidosqualene as inhibitors of oxidosqualene and squalene-hopene cyclases

@article{Rocco2003ConjugatedMS,
  title={Conjugated methyl sulfide and phenyl sulfide derivatives of oxidosqualene as inhibitors of oxidosqualene and squalene-hopene cyclases},
  author={F. Rocco and S. O. Bosso and F. Viola and P. Milla and G. Roma and G. Grossi and M. Ceruti},
  journal={Lipids},
  year={2003},
  volume={38},
  pages={201-207}
}
  • F. Rocco, S. O. Bosso, +4 authors M. Ceruti
  • Published 2003
  • Chemistry, Medicine
  • Lipids
    • Various (1E,3E)- and (1Z,3E)-conjugated methylthio derivatives of oxidosqualene (OS) and conjugated and non-conjugated phenylthio derivatives of OS were obtained. These compounds, designed as inhibitors of pig liver and Saccharomyces cerevisiae 2,3-oxidosqualene-lanosterol cyclases (OSC) (EC 5.4.99.7) and of Alicyclobacillus acidocaldarius squalenehopene cyclase (SHC) (EC 5.4.99.-), contain the reactive function adjacent to carbons involved in the formation of the third and the fourth cycle… CONTINUE READING
    View on Springer
    ncbi.nlm.nih.gov
    4 Citations
    4 Citations
    Citation Type

    Citation Type

    Analogs of squalene and oxidosqualene inhibit oxidosqualene cyclase of Trypanosoma cruzi expressed in Saccharomyces cerevisiae
    • 10
    • PDF
    Synthesis and biological activity of new lodoacetamide derivatives on mutants of squalene-hopene cyclase
    • 8
    IN SILICO MUTATION STUDIES ON THE LIPOPHILIC CHANNEL OF HUMAN OXIDO SQUALENE CYCLASE (OSC) DURING SUBSTRATE ENTRY.
    • PDF
    Squalene-Hopene Cyclase
    • 5

    References

    SHOWING 1-10 OF 47 REFERENCES
    Vinyl sulfide derivatives of truncated oxidosqualene as selective inhibitors of oxidosqualene and squalene-hopene cyclases
    • 40
    Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase.
    • 23
    Synthesis of vinyl sulfide analogs of 2,3-oxidosqualene and their inhibition of 2,3-oxidosqualene lanosterol-cyclases☆
    • 23
    Inhibition of 2,3-oxidosqualene cyclases.
    • 47
    29-Methylidene-2,3-oxidosqualene derivatives as stereospecific mechanism-based inhibitors of liver and yeast oxidosqualene cyclase.
    • 19
    Stereospecific syntheses of trans-vinyldioxidosqualene and 3-hydroxysulfide derivatives, as potent and time-dependent 2,3-oxidosqualene cyclase inhibitors.
    • 10
    Rationally designed inhibitors as tools for comparing the mechanism of squalene-hopene cyclase with oxidosqualene cyclase
    • 15
    Inhibition of 2,3-oxidosqualene cyclase and sterol biosynthesis by 10- and 19-azasqualene derivatives.
    • 24
    Synthesis and biological activity of azasqualenes, bis-azasqualenes and derivatives
    • 64
    Crystal structure of a squalene cyclase in complex with the potential anticholesteremic drug Ro48-8071.
    • 38