Conjugated methyl sulfide and phenyl sulfide derivatives of oxidosqualene as inhibitors of oxidosqualene and squalene-hopene cyclases

@article{Rocco2003ConjugatedMS,
  title={Conjugated methyl sulfide and phenyl sulfide derivatives of oxidosqualene as inhibitors of oxidosqualene and squalene-hopene cyclases},
  author={F. Rocco and S. O. Bosso and F. Viola and P. Milla and G. Roma and G. Grossi and M. Ceruti},
  journal={Lipids},
  year={2003},
  volume={38},
  pages={201-207}
}
  • F. Rocco, S. O. Bosso, +4 authors M. Ceruti
  • Published 2003
  • Chemistry, Medicine
  • Lipids
  • Various (1E,3E)- and (1Z,3E)-conjugated methylthio derivatives of oxidosqualene (OS) and conjugated and non-conjugated phenylthio derivatives of OS were obtained. These compounds, designed as inhibitors of pig liver and Saccharomyces cerevisiae 2,3-oxidosqualene-lanosterol cyclases (OSC) (EC 5.4.99.7) and of Alicyclobacillus acidocaldarius squalenehopene cyclase (SHC) (EC 5.4.99.-), contain the reactive function adjacent to carbons involved in the formation of the third and the fourth cycle… CONTINUE READING
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