Conjugated linoleic acid suppresses myogenic gene expression in a model of human muscle cell inflammation.

@article{Larsen2008ConjugatedLA,
  title={Conjugated linoleic acid suppresses myogenic gene expression in a model of human muscle cell inflammation.},
  author={Amy E. Larsen and David Cameron-Smith and Timothy C. Crowe},
  journal={The Journal of nutrition},
  year={2008},
  volume={138 1},
  pages={
          12-6
        }
}
Proinflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, contribute to muscle wasting in inflammatory disorders, where TNFalpha acts to regulate myogenic genes. Conjugated linoleic acid (CLA) has shown promise as an antiproliferative and antiinflammatory agent, leading to its potential as a therapeutic agent in muscle-wasting disorders. To evaluate the effect of CLA on myogenesis during inflammation, human primary muscle cells were grown in culture and exposed to varying… CONTINUE READING
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