Conjugated linoleic acid metabolism

@article{Banni2002ConjugatedLA,
  title={Conjugated linoleic acid metabolism},
  author={Sebastiano Banni},
  journal={Current Opinion in Lipidology},
  year={2002},
  volume={13},
  pages={261-266}
}
  • S. Banni
  • Published 1 June 2002
  • Chemistry
  • Current Opinion in Lipidology
Conjugated linoleic acid (CLA) is a naturally occurring fatty acid that is produced by a bio-hydrogenation process in the rumen, and thus is present in dairy products and ruminant meat. In this case the predominant isomer formed is 9cis,11trans. However, CLA includes 28 positional and geometrical isomers, of which only 9cis,11trans and 10trans,12cis have thus far been proven to possess biological activities. Both of these CLA isomers have been shown to undergo elongation and desaturation… 

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In 1979, a research group from the University of WisconsinMadison detected a compound with anti-mutagenic activity in ground beef extract (Pariza and Hargraves, 1985); because of its structural
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References

SHOWING 1-10 OF 62 REFERENCES

Metabolites of conjugated isomers of linoleic acid (CLA) in the rat.

Distribution of conjugated linoleic acid and metabolites in different lipid fractions in the rat liver.

The uptake of c 9,t11-CLA and its downstream metabolites into various lipid fractions in the liver of rats fed either a high or low CLA diet (containing 0.1 or 0.8 g CLA/100 g diet, respectively) was investigated to investigate the role of CLA in modulating eicosanoid metabolism.

Changes in conjugated linoleic acid and its metabolites in patients with chronic renal failure.

The increased levels of CLA in plasma and adipose tissue of end-stage CRF patients may be due either to a reduced metabolization of CLA to CD18:3 and CD20:3, or to an altered site distribution with reduced incorporation in cellular membranes and accumulation in the plasma and leptin tissue.

The effect of conjugated linoleic acid isomers on fatty acid profiles of liver and adipose tissues and their conversion to isomers of 16∶2 and 18∶3 conjugated fatty acids in rats

The 9cis,11trans- and the 10trans,12cis-CLA isomers are metabolized differently and have distinct effects on the metabolism of polyunsaturated fatty acids in rat liver while altering liver triglyceride levels differentially.

Conjugated linoleic acid and oxidative stress

Fatty acid analyses of lamb and rats fed CLA at levels known to prevent carcinogenesis showed that CLA and its metabolites steadily decreased during oxidative stress and that they are more prone to oxidation than their corresponding methylene-interrupted fatty acids.

Modulation of prostaglandin H synthase activity by conjugated linoleic acid (CLA) and specific CLA isomers

The results of this study demonstrate the potential of CLA and specific isomers of CLA to modulate prostaglandin biosynthesis and the efficacy differs for each isomer, with the 9(Z),11(E) CLA isomer being the most effective and the9(Z,11(Z) CLA has been the least effective inhibitor.

Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha.

CLA is a high affinity ligand and activator of peroxisome proliferator-activated receptor alpha (PPARalpha) and induces accumulation of PPAR-responsive mRNAs in a rat hepatoma cell line and its effects on lipid metabolism may be attributed to transcriptional events associated with this nuclear receptor.

Vaccenic Acid Feeding Increases Tissue Levels of Conjugated Linoleic Acid and Suppresses Development of Premalignant Lesions in Rat Mammary Gland

It is hypothesized that the anticancer response to vaccenic acid is likely to be mediated by its endogenous conversion to CLA via Δ2-desaturase, and could substitute for CLA as an anticancer agent.
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