Conjugated linoleic acid metabolism

  title={Conjugated linoleic acid metabolism},
  author={Sebastiano Banni},
  journal={Current Opinion in Lipidology},
  • S. Banni
  • Published 1 June 2002
  • Chemistry
  • Current Opinion in Lipidology
Conjugated linoleic acid (CLA) is a naturally occurring fatty acid that is produced by a bio-hydrogenation process in the rumen, and thus is present in dairy products and ruminant meat. In this case the predominant isomer formed is 9cis,11trans. However, CLA includes 28 positional and geometrical isomers, of which only 9cis,11trans and 10trans,12cis have thus far been proven to possess biological activities. Both of these CLA isomers have been shown to undergo elongation and desaturation… 

Conjugated Linoleic Acid: Biosynthesis and Nutritional Significance

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Metabolism of c9,t11-conjugated linoleic acid (CLA) in humans.

Conjugated linoleic acids (CLA) as precursors of a distinct family of PUFA

CLA isomers may be viewed as a “new” family of polyunsaturated fatty acids (PUFA) producing a distinct range of metabolites using the same enzymatic system as the other PUFA families.

Conjugated Linoleic Acid: Chemical Structure, Sources and Biological Properties

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The objective of this review is to provide an overview regarding factors affecting CLA composition, its synthesis in ruminants and its impacts on human health.

Analysis of conjugated linoleic acid and trans 18:1 isomers in synthetic and animal products.

Improved techniques are used to evaluate the CLA profile in pork products from pigs fed different commercial CLA mixtures, and are essential to evaluate dairy fats for their CLA content, to design experimental diets to increase the amount of CLA in dairy fats, and to determine theCLA profile in these CLA-enriched dairy fats.

The biologically active isomers of conjugated linoleic acid.

Conjugated linoleic acid and atherosclerosis: studies in animal models.

This review will examine the evidence for and against a role for CLA in atherosclerosis, with a focus on the rabbit, the hamster, and the apoE-deficient mouse.

Biological effects of conjugated linoleic acids in health and disease.

The Metabolic Effects of Conjugated Linoleic

In 1979, a research group from the University of WisconsinMadison detected a compound with anti-mutagenic activity in ground beef extract (Pariza and Hargraves, 1985); because of its structural



Metabolites of conjugated isomers of linoleic acid (CLA) in the rat.

Distribution of conjugated linoleic acid and metabolites in different lipid fractions in the rat liver.

The uptake of c 9,t11-CLA and its downstream metabolites into various lipid fractions in the liver of rats fed either a high or low CLA diet (containing 0.1 or 0.8 g CLA/100 g diet, respectively) was investigated to investigate the role of CLA in modulating eicosanoid metabolism.

Changes in conjugated linoleic acid and its metabolites in patients with chronic renal failure.

The increased levels of CLA in plasma and adipose tissue of end-stage CRF patients may be due either to a reduced metabolization of CLA to CD18:3 and CD20:3, or to an altered site distribution with reduced incorporation in cellular membranes and accumulation in the plasma and leptin tissue.

The effect of conjugated linoleic acid isomers on fatty acid profiles of liver and adipose tissues and their conversion to isomers of 16∶2 and 18∶3 conjugated fatty acids in rats

The 9cis,11trans- and the 10trans,12cis-CLA isomers are metabolized differently and have distinct effects on the metabolism of polyunsaturated fatty acids in rat liver while altering liver triglyceride levels differentially.

Conjugated linoleic acid and oxidative stress

Fatty acid analyses of lamb and rats fed CLA at levels known to prevent carcinogenesis showed that CLA and its metabolites steadily decreased during oxidative stress and that they are more prone to oxidation than their corresponding methylene-interrupted fatty acids.

Modulation of prostaglandin H synthase activity by conjugated linoleic acid (CLA) and specific CLA isomers

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Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha.

CLA is a high affinity ligand and activator of peroxisome proliferator-activated receptor alpha (PPARalpha) and induces accumulation of PPAR-responsive mRNAs in a rat hepatoma cell line and its effects on lipid metabolism may be attributed to transcriptional events associated with this nuclear receptor.

Vaccenic Acid Feeding Increases Tissue Levels of Conjugated Linoleic Acid and Suppresses Development of Premalignant Lesions in Rat Mammary Gland

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