Conjugated linoleic acid and bone biology.

  title={Conjugated linoleic acid and bone biology.},
  author={Bruce A. Watkins and Mark F. Seifert},
  journal={Journal of the American College of Nutrition},
  volume={19 4},
Osteoporosis, osteoarthritis and inflammatory joint disease afflict millions of people worldwide. Inflammatory cytokines inhibit chondrocyte proliferation and induce cartilage degradation for which part of the response is mediated by PGE2. Excess production of PGE2 is linked to osteoporosis and arthritis and is associated with bone and proteoglycan loss. PGE2 also influences the IGF-I/IGFBP axis to facilitate bone and cartilage formation. Recent investigations with growing rats given butter fat… CONTINUE READING
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