Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling.

@article{Fang2007ConjugatedBA,
  title={Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling.},
  author={Youwen Fang and Elaine J. Studer and Clint Mitchell and Steven Grant and William M. Pandak and Philip B. Hylemon and Paul Dent},
  journal={Molecular pharmacology},
  year={2007},
  volume={71 4},
  pages={1122-8}
}
The regulation of glycogen synthase activity by bile acids in primary hepatocytes and in the intact liver was investigated. Bile acids (deoxycholic acid, DCA; taurocholic acid, TCA) activated AKT and glycogen synthase (GS) in primary rat hepatocytes. Incubation with a phosphatidyl inositol-3 kinase inhibitor or expression of dominant-negative AKT in primary rat hepatocytes abolished activation of AKT and GS by DCA and TCA. TCA, but not DCA, activated Galpha(i) proteins in primary rat… CONTINUE READING

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