Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2

@inproceedings{Liu2014ConjugatedBA,
  title={Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2},
  author={Runping Liu and Renping Zhao and Xiqiao Zhou and Xiuyin Liang and Deanna J W Campbell and Xiaoxuan Zhang and Lu-yong Zhang and Ruihua Shi and Guang-ji Wang and William M. Pandak and Alphonse E. Sirica and Phillip B. Hylemon and Huiping Zhou},
  booktitle={Hepatology},
  year={2014}
}
UNLABELLED Cholangiocarcinoma (CCA) is an often fatal primary malignancy of the intra- and extrahepatic biliary tract that is commonly associated with chronic cholestasis and significantly elevated levels of primary and conjugated bile acids (CBAs), which are correlated with bile duct obstruction (BDO). BDO has also recently been shown to promote CCA progression. However, whereas there is increasing evidence linking chronic cholestasis and abnormal bile acid profiles to CCA development and… CONTINUE READING
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