Conjugated Linoleic Acid Isomers Reduce Cholesterol Accumulation in Acetylated LDL-Induced Mouse RAW264.7 Macrophage-Derived Foam Cells

@article{Ringseis2008ConjugatedLA,
  title={Conjugated Linoleic Acid Isomers Reduce Cholesterol Accumulation in Acetylated LDL-Induced Mouse RAW264.7 Macrophage-Derived Foam Cells},
  author={Robert Ringseis and Gaiping Wen and Daniela Saal and Klaus Eder},
  journal={Lipids},
  year={2008},
  volume={43},
  pages={913-923}
}
Synthetic activators of peroxisome proliferator-activated receptors (PPAR)-α and -γ are capable of reducing macrophage foam cell cholesterol accumulation through the activation of genes involved in cholesterol homeostasis. Since conjugated linoleic acids (CLA) were also demonstrated to activate PPARα and PPARγ in vivo and in vitro, we tested the hypothesis that CLA are also capable of reducing macrophage foam cell cholesterol accumulation. Thus, mouse RAW264.7 macrophage-derived foam cells were… CONTINUE READING
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PPARc-LXRABCA1 Pathway in macrophages is involved in cholesterol efflux and atherogenesis

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