Conjugated EPA activates mutant p53 via lipid peroxidation and induces p53-dependent apoptosis in DLD-1 colorectal adenocarcinoma human cells.

@article{Tsuzuki2007ConjugatedEA,
  title={Conjugated EPA activates mutant p53 via lipid peroxidation and induces p53-dependent apoptosis in DLD-1 colorectal adenocarcinoma human cells.},
  author={Tsuyoshi Tsuzuki and Tomoko Kambe and Akira Shibata and Yuki Kawakami and Kiyotaka Nakagawa and Teruomi Miyazawa},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1771 1},
  pages={
          20-30
        }
}
Both conjugated linoleic acid (CLA), which contains conjugated double bonds, and eicosapentaenoic acid (EPA), an n-3 polyunsaturated fatty acid, have antitumor effects. Hence, we hypothesized that a combination of conjugated double bonds and an n-3 highly unsaturated fatty acid may produce a stronger antitumor effect, and we have previously shown that conjugated EPA (CEPA), prepared by alkaline treatment of EPA, induces strong and selective apoptosis in vitro and in vivo, with the mechanism… CONTINUE READING
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