Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells

@article{Muratovska2004ConjugateFE,
  title={Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells},
  author={Aleksandra Muratovska and Michael R. Eccles},
  journal={FEBS Letters},
  year={2004},
  volume={558}
}
The efficient delivery of short interfering RNAs (siRNAs) into cells provides a powerful approach to study cellular functions. SiRNAs were coupled to the membrane permeant peptides (MPPs) penetratin and transportan to improve their uptake by cells. Thiol‐containing siRNAs corresponding to luciferase, or green fluorescent protein (GFP) transgenes, were synthesized and conjugated to penetratin or transportan via a disulfide bond that is labile in the reducing environment of the cytoplasm. These… 
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