Conjugate addition reactions combined with free-radical cross-linking for the design of materials for tissue engineering.

@article{Elbert2001ConjugateAR,
  title={Conjugate addition reactions combined with free-radical cross-linking for the design of materials for tissue engineering.},
  author={Donald L. Elbert and Jeffrey A Hubbell},
  journal={Biomacromolecules},
  year={2001},
  volume={2 2},
  pages={430-41}
}
PEG-diacrylamide was synthesized and utilized to make materials for tissue engineering. Acrylamide groups readily react with thiol groups, and peptides containing a single thiol group were coupled to the PEG-diacrylamide in aqueous solution at room temperature in about 2 h. If only a portion of the acrylamide groups were targeted for reaction with peptide, sufficient amounts of PEG-diacrylamide remained to be polymerized by free-radical mechanisms via photoinitiation. The photopolymerization… CONTINUE READING

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