Conjugate Addition Reactions of Some Methylidene 1-Benzylpyrimidinetrione Derivatives

@inproceedings{Abdelghani2001ConjugateAR,
  title={Conjugate Addition Reactions of Some Methylidene 1-Benzylpyrimidinetrione Derivatives},
  author={Essam Abdelghani},
  year={2001}
}
1-Benzyl-2,4,6-pyrimidinetrione (1) reacts at C-5 with aldehydes and the isolated products can easily undergo base-induced transformations by Michael addition. On the contrary,the action of POCl 3 or piperidine/AcOH on the title trione afforded pyrimido[4,5:4,5]furo[2,3-d]pyrimidine (16) and a dimer (17), respectively, which in turn, undergo cyclocondensation in Ac 2 O.