Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatus Interferes with the Host Endocytosis Pathway

@inproceedings{Thywissen2011ConidialDM,
  title={Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatus Interferes with the Host Endocytosis Pathway},
  author={Andreas Thywissen and Thorsten Heinekamp and H. M. Dahse and Jeannette Schmaler-Ripcke and S{\'a}ndor Nietzsche and Peter F Zipfel and Axel A. Brakhage},
  booktitle={Front. Microbio.},
  year={2011}
}
Aspergillus fumigatus is the most important air-borne fungal pathogen of humans. The interaction of the pathogen with the host's immune system represents a key process to understand pathogenicity. For elimination of invading microorganisms, they need to be efficiently phagocytosed and located in acidified phagolysosomes. However, as shown previously, A. fumigatus is able to manipulate the formation of functional phagolysosomes. Here, we demonstrate that in contrast to pigmentless pksP mutant… CONTINUE READING

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