Congo red-stabilized intermediates in the lambda light chain transition from native to molten state.

@article{Piekarska1996CongoRI,
  title={Congo red-stabilized intermediates in the lambda light chain transition from native to molten state.},
  author={Barbara Piekarska and Marek Skowronek and Janina Rybarska and Barbara Stopa and Irena Roterman and Leszek Konieczny},
  journal={Biochimie},
  year={1996},
  volume={78 3},
  pages={
          183-9
        }
}
Disruption of tertiary interaction makes a protein accessible to penetration by different small molecular compounds. Their interaction may stabilize the altered protein conformation. Congo red is proposed here as a stabilizer of the molten globule state and also of highly reversible intermediates in the transition from native to molten state. Human immunoglobulin lambda light chain (dimer) was used. Two protein-Congo red complexes were found after heating lambda chain in the presence of Congo… CONTINUE READING

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