Congo red and thioflavin-T analogs detect Abeta oligomers.

  title={Congo red and thioflavin-T analogs detect Abeta oligomers.},
  author={Izumi Maezawa and H Hong and Ruiwu Liu and Chun-Yi Wu and Russell C. H. Cheng and M. -P. Kung and Hank F Kung and Kit S Lam and Salvatore Oddo and Frank M Laferla and Lee-way Jin},
  journal={Journal of neurochemistry},
  volume={104 2},
Several small molecule ligands for amyloid-beta (Abeta) fibrils deposited in brain have been developed to facilitate radiological diagnosis of Alzheimer's disease (AD). Recently, the build-up of Abeta oligomers (AbetaO) in brain has been recognized as an additional hallmark of AD and may play a more significant role in early stages. Evidence suggests that quantitative assessment of AbetaO would provide a more accurate index of therapeutic effect of drug trials. Therefore, there is an urgent… CONTINUE READING


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