Congo red and protein aggregation in neurodegenerative diseases

  title={Congo red and protein aggregation in neurodegenerative diseases},
  author={Petrea Frid and Sergey V. Anisimov and Natalija Popovic},
  journal={Brain Research Reviews},
Congo red is a commonly used histological dye for amyloid detection. The specificity of this staining results from Congo red's affinity for binding to fibril proteins enriched in beta-sheet conformation. Unexpectedly, recent investigations indicate that the dye also possesses the capacity to interfere with processes of protein misfolding and aggregation, stabilizing native protein monomers or partially folded intermediates, while reducing concentration of more toxic protein oligomers… CONTINUE READING


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