Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials

@article{Lago2007CongestiveHF,
  title={Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials},
  author={Rodrigo M. Lago and Premranjan P. Singh and Richard W. Nesto},
  journal={The Lancet},
  year={2007},
  volume={370},
  pages={1129-1136}
}
BACKGROUND The overall clinical benefit of thiazolidinediones (TZDs) as a treatment for hyperglycaemia can be difficult to assess because of the risk of congestive heart failure due to TZD-related fluid retention. Since prediabetic and diabetic patients are at high cardiovascular risk, the outcome and natural history of such risks need to be better understood. We aimed to examine the risk of congestive heart failure and of cardiac death in patients given TZDs. METHODS We used a search… CONTINUE READING
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Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones : a meta - analysis of randomised clinical trials

SE Nissen, K Wolski