Congestive heart failure alters receptor-dependent cAMP-mediated relaxation of canine pulmonary arteries.

@article{Mathew1993CongestiveHF,
  title={Congestive heart failure alters receptor-dependent cAMP-mediated relaxation of canine pulmonary arteries.},
  author={Rajamma Mathew and Ji-shi Wang and Michael H. Gewitz and Thomas H. Hintze and Michael S. Wolin},
  journal={Circulation},
  year={1993},
  volume={87 5},
  pages={1722-8}
}
BACKGROUND Alterations in myocardial function and systemic vascular tone are well documented in congestive heart failure (CHF), but little information is available on the effects of CHF on pulmonary vessels. We examined the mechanisms of tone regulation of canine pulmonary arteries during pacing-induced CHF. METHODS AND RESULTS Rings 3-4 mm wide from lobar pulmonary arteries were prepared from normal dogs, dogs paced at 210 beats per minute for 3 weeks (paced group, nonfailure), and dogs also… CONTINUE READING