Congenital thyrotoxicosis in premature infants.

  title={Congenital thyrotoxicosis in premature infants.},
  author={Claire Smith and Michael J. Thomsett and Catherine Choong and Christine Rodda and Harold D McIntyre and Andrew M Cotterill},
  journal={Clinical endocrinology},
  volume={54 3},
OBJECTIVES Graves' disease (GD) complicates 0.1% to 0.2% of pregnancies, but congenital thyrotoxicosis is rare occurring in one in 70 of these pregnancies independent of maternal disease status. Antenatal prediction of affected infants is imprecise; however, maternal history, coupled with a high maternal serum TSH receptor binding immunoglobulin index (TBII) predict adverse neonatal outcome. Mortality is reported to be as high as 25% in affected infants and would therefore be expected to be… CONTINUE READING