Congenital stationary night blindness in the dog: common mutation in the RPE65 gene indicates founder effect.

@article{Aguirre1998CongenitalSN,
  title={Congenital stationary night blindness in the dog: common mutation in the RPE65 gene indicates founder effect.},
  author={Gustavo D. Aguirre and Victoria J Baldwin and S Pearce-kelling and Kristina L Narfstr{\"o}m and Kaitlin A Ray and Gregory M. Acland},
  journal={Molecular vision},
  year={1998},
  volume={4},
  pages={23}
}
PURPOSE To clone and characterize the canine RPE65 cDNA from normal dog, examine for mutations, and establish if the mutation identified in Swedish briard dogs with retinal dystrophy is present in dogs of the same breed that originated from the United States and other countries, and are affected with congenital stationary night blindness. METHODS Fifteen briard dogs were studied, of which 10 were affected with csnb, and five were clinically normal. In addition, we tested samples from four… CONTINUE READING
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