Congenital risk factors for schizophrenia

  title={Congenital risk factors for schizophrenia},
  author={S. Lewis},
  journal={Psychological Medicine},
  pages={5 - 13}
  • S. Lewis
  • Published 1 February 1989
  • Psychology, Medicine
  • Psychological Medicine
Mise au point sur les facteurs congenitaux de risque (developpement perturbe du systeme nerveux, complications obstetricales)^ concernant la schizophrenie 

Schizophrenic Psychosis and Associated Aqueduct Stenosis

In two adults, both schizophrenia and hydrocephalus were associated with aqueduct stenosis. The prevalence is argued to be above chance, and may contribute to the neurodevelopmental hypothesis of the

Can Brain Damage Protect Against Schizophrenia?

In a pair of male monozygotic twins discordant for schizophrenia, MRI revealed no abnormality in the ill proband, but extensive white-matter damage of likely congenital origin in the psychiatrically normal twin, raising the possibility that some forms of brain damage may preclude expression of the schizophrenia genotype.

Schizophrenia: prenatal influenza and autoimmunity.

The schizophrenic syndrome may represent a stereotyped response by the developing brain to various insults, including micro-organisms, and the hypothesis that exposure to influenza during fetal life increases the risk of later schizophrenia is examined.

Schizophrenics with a family history of bipolar disorder. Possible involvement of obstetric complications

The case reports of two DSM III-R schizophrenic patients with a family history of bipolar disorder are presented and their cases are discussed in the light of neurodevelopmental theories of schizophrenia and in the continuum view of psychosis.

Schizencephaly associated with psychosis

The implications of the association between schizencephaly and psychosis in these patients for understanding the biology of the psychoses are discussed and two patients are described with clear psychotic symptoms with either unilateral or bilateral schiziaphaly.

A hypothesis on the abnormal seasonality of schizophrenic births

It is proposed that the abnormal seasonality of schizophrenic births is partly a consequence of seasonal variations of conception and of an associated seasonal variation of risk of premature delivery.

Obstetric Complications and Schizophrenia a Case-Control Study

A group of schizophrenic patients with their siblings and controls, on the basis of obstetric files stemming from the same University Hospital Maternity Ward, had more frequent umbilical cord complications and atypical presentations, as well as higher scores on a scale measuring OCs linked to possible neonatal asphyxia.

Are Polioviruses a Cause of Schizophrenia?

  • J. Eagles
  • Medicine, Psychology
    British Journal of Psychiatry
  • 1992
The hypothesis of a genetic link between schizophrenia and susceptibility to poliomyelitis is generated from the declining incidence of schizophrenia, the excess of schizophrenic winter births, and the increased rates of schizophrenia among West Indian immigrants.



Obstetric complications, neurodevelopmental deviance, and risk of schizophrenia.

Prevalence of Familiality, Obstetric Complications, and Structural Brain Damage in Schizophrenic Patients

The two groups of schizophrenia in-patients with and without a family history did not differ with respect to clinical variables, ventricular enlargement, prevalence of cortical sulcal widening, or a history of obstetric complications, when a variety of definitions of familiality were used.

Perinatal Complications and Clinical Outcome within the Schizophrenia Spectrum

It is proposed that birth complications can decompensate borderline individuals towards schizophrenic breakdown and be interpreted in terms of a 'diathesis-stress' model.

Aqueduct stenosis and schizophrenia

Three patients with hydrocephalus and aqueduct stenosis are described, who also have schizophrenia defined according to strict diagnostic criteria. There are no previous reports of such an

Paranatal Complications in Hospitalized Schizophrenic and Nonschizophrenic Patients

This investigation was concerned with the relation of pre- and perinatal complications to evidence of cerebral dysfunction in patients hospitalized with functional psychiatric disorders.

Viruses, neurodevelopmental disorder and childhood psychosis.

  • K. NunnB. LaskM. Cohen
  • Medicine, Psychology
    Journal of child psychology and psychiatry, and allied disciplines
  • 1986
The emergence of potent anti-viral treatments and sophisticated methods of identifying the presence of viral infection should encourage us to consider more carefully the relevance of viruses in childhood psychosis.

Are Complications of Pregnancy and Birth Causes of Schizophrenia?

  • R. Goodman
  • Medicine, Psychology
    Developmental medicine and child neurology
  • 1988
There has recently been increased psychiatric interest in the hypothesis that complications of pregnancy and birth cause schizophrenia, and practitioners of developmental medicine are in a position to make a unique contribution to this aspect of schizophrenia research.

Brain imaging in a case of Capgras' syndrome.

  • S. Lewis
  • Psychology, Medicine
    The British journal of psychiatry : the journal of mental science
  • 1987
A patient developed Capgras' syndrome as part of an interictal psychosis of epilepsy; magnetic resonance imaging revealed bilateral subcortical lesions in occipitotemporal and frontal regions. These

Schizophrenia-Like Psychosis Associated with Vein of Galen Malformation: A Case Report

  • A. AleemM. Knesevich
  • Medicine, Psychology
    Canadian journal of psychiatry. Revue canadienne de psychiatrie
  • 1987
The relevance of the association of vein of Galen AVMs with schizophrenia-like symptomatology is discussed, and a 34 year old patient presented with a schizophrenialike clinical picture, and was later found to have a large vein ofGalen Arteriovenous Malformation.

Neurobiologic antecedents of schizophrenia in children. Evidence for an inherited, congenital neurointegrative defect.

  • B. Fish
  • Psychology, Medicine
    Archives of general psychiatry
  • 1977
Preschizophrenic infants show a fluctuating dysregulation of maturation that involves physical growth; gross motor, visual-motor, and cognitive development; proprioceptive and vestibular responses; muscle tone; and possibly arousal.