Congenital leptin deficiency is associated with severe early-onset obesity in humans

@article{Montague1997CongenitalLD,
  title={Congenital leptin deficiency is associated with severe early-onset obesity in humans},
  author={Carl T. Montague and I Sadaf Farooqi and Jonathan P. Whitehead and Maria A. Soos and Harald Rau and Nicholas J. Wareham and Ciaran P Sewter and Janet E. Digby and Shehla Mohammed and Jane A. Hurst and Christopher Cheetham and Alison R. Earley and Anthony H. Barnett and Johannes B. Prins and Stephen O’Rahilly},
  journal={Nature},
  year={1997},
  volume={387},
  pages={903-908}
}
The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene encoding leptin, an adipocyte-specific secreted protein which has profound effects on appetite and energy expenditure. We know of no equivalent evidence regarding leptin's role in the control of fat mass in humans. We have examined two severely obese children who are members of the same highly consanguineous pedigree. Their serum leptin levels were very low despite their markedly elevated fat mass and, in… 
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TLDR
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TLDR
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