Congenital leptin deficiency is associated with severe early-onset obesity in humans

  title={Congenital leptin deficiency is associated with severe early-onset obesity in humans},
  author={C. T. Montague and I. Farooqi and J. P. Whitehead and M. Soos and H. Rau and N. Wareham and C. Sewter and J. Digby and S. Mohammed and J. Hurst and C. Cheetham and A. Earley and A. Barnett and J. Prins and S. O'Rahilly},
  • C. T. Montague, I. Farooqi, +12 authors S. O'Rahilly
  • Published 1997
  • Biology, Medicine
  • Nature
  • The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene encoding leptin, an adipocyte-specific secreted protein which has profound effects on appetite and energy expenditure. We know of no equivalent evidence regarding leptin's role in the control of fat mass in humans. We have examined two severely obese children who are members of the same highly consanguineous pedigree. Their serum leptin levels were very low despite their markedly elevated fat mass and, in… CONTINUE READING
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