Congenital heart disease in mice deficient for the DiGeorge syndrome region

@article{Lindsay1999CongenitalHD,
  title={Congenital heart disease in mice deficient for the DiGeorge syndrome region},
  author={Elizabeth Anne Lindsay and Annalisa Botta and Vesna Jurecic and Sandra Carattini-Rivera and Yin-Chai Cheah and Howard M. Rosenblatt and Allan Bradley and Antonio Baldini},
  journal={Nature},
  year={1999},
  volume={401},
  pages={379-383}
}
The heterozygous chromosome deletion within the band 22q11 (del22q11) is an important cause of congenital cardiovascular defects1. It is the genetic basis of DiGeorge syndrome and causes the most common deletion syndrome in humans2. Because the deleted region is largely conserved in the mouse, we were able to engineer a chromosome deletion (Df1) spanning a segment of the murine region homologous to the human deleted region. Here we describe heterozygously deleted (Df1/+) mice with… CONTINUE READING
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