Antibodies to Mitotic Spindle Apparatus: Clinical Significance of NuMA and HsEg5 Autoantibodies
was 9.4 g/dl, the haematocrit was 29.1%, the platelet count was 494 000/mmand theC-reactive proteinwas 141mg/l.Gastroscopy, colonoscopy and CT scanning showed no abnormalities. For further evaluation, the patient was admitted for [F]FDGPET, which clearly demonstrated pathologically elevated glucose uptake within the vessel wall of the whole aorta (Fig. 1A, arrow) and its main thoracic and abdominal branches. The diagnosis of large-vessel vasculitis was subsequently confirmed by the finding of giant cell infiltration (Fig. 1B, arrow) with thickening of all temporal artery layers and consecutive stenosis of the lumen. The patient was treated with prednisone and recovery was unremarkable. Due to its high sensitivity, especially in the state of active inflammation , [F]FDG-PET might become a valuable diagnostic tool in the management of large-vessel inflammation.