Congenital diaphragmatic hernia, tracheal occlusion, thyroid transcription factor-1, and fetal pulmonary epithelial maturation.

@article{Chapin2005CongenitalDH,
  title={Congenital diaphragmatic hernia, tracheal occlusion, thyroid transcription factor-1, and fetal pulmonary epithelial maturation.},
  author={Cheryl J. Chapin and Robert D Ertsey and Jyoji Yoshizawa and Akihiko Hara and Lourenço N Sbragia and John J. Greer and Joseph A. Kitterman},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2005},
  volume={289 1},
  pages={L44-52}
}
Congenital diaphragmatic hernia (CDH) occurs in approximately 1:2,500 human births and has high morbidity and mortality rates, primarily due to pulmonary hypoplasia and pulmonary hypertension. Tracheal occlusion (TO), in experimental animals, distends lungs and increases lung growth and alveolar type I cell maturation but decreases surfactant components and reduces alveolar type II cell density. We examined effects of CDH and CDH+TO on lung growth and maturation in fetal rats. To induce CDH, we… CONTINUE READING

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