Congenital anomalies in relatives of schizophrenic probands may indicate a retinoid pathology

@article{Goodman1996CongenitalAI,
  title={Congenital anomalies in relatives of schizophrenic probands may indicate a retinoid pathology},
  author={Ann B. Goodman},
  journal={Schizophrenia Research},
  year={1996},
  volume={19},
  pages={163-170}
}
  • A. Goodman
  • Published 1996
  • Medicine, Psychology
  • Schizophrenia Research
Retinoic acid, the morphogenic derivative of vitamin A, has been shown to alter patterns of neurulation and to regulate the expression of many genes involved in central nervous system development. Retinoid toxicity can result in craniofacial, limb, digit, heart and urogenital abnormalities. Hydrocephalus, due to increased ventricular size and/or decreased size of the hind- or forebrain, occurs frequently. Comparison of the frequency and type of congenital anomalies in extended pedigrees of 12… Expand
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The knowledge about the transport, delivery, and action of retinoids is related to what is presently known about the pathology of schizophrenia, with particular reference to the dopamine hypothesis, neurotransmitters, the glutamate hypothesis, retinitis pigmentosa, dermatologic disorders, and craniofacial anomalies. Expand
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