Congenital acute T lymphoblastic leukaemia: report of a case with immunohistochemical and molecular characterisation.

@article{Tao2000CongenitalAT,
  title={Congenital acute T lymphoblastic leukaemia: report of a case with immunohistochemical and molecular characterisation.},
  author={Jianguo Tao and E. Robles Valderrama and Leonard Kahn},
  journal={Journal of clinical pathology},
  year={2000},
  volume={53 2},
  pages={150-2}
}
A newborn infant with congenital T cell lymphoblastic leukaemia presented with hepatosplenomegaly and pancytopenia at birth and died on the 21st day of multi-organ failure. Biopsy and necropsy examination showed extensive atypical lymphoid infiltrates in the lungs, liver, spleen, kidneys, lymph nodes, and bone marrow. Immunohistochemically, the lymphoid cells were TdT+, CD3+, CD45RO+, and CD10-, CD79a-, CD20-. Genotypic analysis using polymerase chain reaction showed T cell receptor gamma chain… CONTINUE READING