Congenital abnormalities in nickel poisoning in chick embryos

  title={Congenital abnormalities in nickel poisoning in chick embryos},
  author={S H Gilani and Marco Marano},
  journal={Archives of Environmental Contamination and Toxicology},
  • S. Gilani, M. Marano
  • Published 1980
  • Biology, Medicine
  • Archives of Environmental Contamination and Toxicology
Experiments were conducted to evaluate the teratogenic potential of nickel chloride given to developing chick embryos. Nickel chloride was dissolved in saline and injected into chicken eggs at dosages ranging from 0.02 to 0.7 mg per egg. The injections were made into the air sacs of eggs at days 0, 1, 2, 3, and 4 of incubation. Control eggs were injected with an equivalent volume of saline (0.1 ml per egg); in all, 840 chicken eggs were used. All embryos were examined on day eight. The… 

Teratogenicity of metals to chick embryos.

It was showed that the metals tested were both toxic and teratogenic to varying degrees in chick embryogenesis, and Arsenic and cobalt were observed to be more Teratogenic than other metals.

Embryotoxicity and Teratogenicity of Nickel Compounds

The present observations suggest that increased erythropoietin activity in maternal serum does not stimulate erythrocytosis in the fetus.

Effect of simultaneous exposure to nickel chloride and benzo(a)pyrene on developing chick embryos.

The mortality and malformations experienced in the chick embryos exposed to BP alone and NiCl2 alone were seen to be added when both the chemicals were simultaneously inoculated into the same chick eggs.

Teratogenicity of Ni2+ inXenopus laevis, assayed by the FETAX procedure

Xenopus embryos were most susceptible to Ni2+-induced malformations on the second and third days of life, during the most active period of organogenesis.

Teratogenicity and embryotoxicity of nickel carbonyl in Syrian hamsters.

It is demonstrated that Ni(CO)4 is teratogenic and embryotoxic in Syrian hamsters and Neonatal mortality was increased in Ni( CO)4-exposed litters.

Ocular malformations of Xenopus laevis exposed to nickel during embryogenesis.

It is confirmed that Ni2+ is a potent ocular teratogen for Xenopus embryos and points to the retinal pigment epithelium as a primary cellular target for Ni(2+)-induced embryotoxicity.

Two-year toxicity and carcinogenicity study of methyleugenol in F344/N rats and B6C3F(1) mice.

Results demonstrate that MEG is a multisite, multispecies carcinogen and shows a positive trend in the incidences of squamous cell papilloma or carcinoma (combined).

Effects of dietary nickel on survival and growth of mallard ducklings

Mallard (Anas platyrhynchos) ducklings were fed nickel sulphate in their diet from day one to 90 days of age and began to tremor and show signs of paresis after 14 days of dosage (age) and 71% of this group died within 60 years of age.



Abnormalities in Chick Embryos Following Thalidomide and Other Insoluble Compounds in the Amniotic Cavity.∗

  • A. WilliamsonR. BlattnerH. Lutz
  • Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1963
Thalidomide produced encephalocele, eyelid defects and beak defects in a significant percentage of chick embryos inoculated into the amnion with the drug at 3 through 6 days incubation, while 4 other selected compounds which remained in an undissolved state in theAmniotic cavity after inoculation produced the same types of defects.