Congenital NOS2 deficiency prevents impairment of hypoxic pulmonary vasoconstriction in murine ventilator-induced lung injury.

@article{Liu2007CongenitalND,
  title={Congenital NOS2 deficiency prevents impairment of hypoxic pulmonary vasoconstriction in murine ventilator-induced lung injury.},
  author={Rong Liu and Yukako Hotta and Amanda Graveline and Oleg V. Evgenov and Emmanuel S Buys and Kenneth D. Bloch and Fumito Ichinose and Warren M. Zapol},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={293 5},
  pages={L1300-5}
}
Hypoxic pulmonary vasoconstriction (HPV) preserves systemic arterial oxygenation during lung injury by diverting blood flow away from poorly ventilated lung regions. Ventilator-induced lung injury (VILI) is characterized by pulmonary inflammation, lung edema, and impaired HPV leading to systemic hypoxemia. Studying mice congenitally deficient in inducible nitric oxide synthase (NOS2) and wild-type mice treated with a selective NOS2 inhibitor, L-N(6)-(1-iminoethyl)lysine (L-NIL), we investigated… CONTINUE READING